The objective of this work was to study the protective effect of wheat germpowder and oil on  high fat and high fructose diet induced metabolic disturbances in rats. Thirty six male rats were distributed into (6) groups (6 rats) as following: Group (1): normal control rats (-ve) fed on basal diet, Group (2): fed on basal diet contained wheat germ powder 20 % , Group (3): fed on basal diet and received wheat germ oil (1.5 ml / kg.bw /day) orally , Group (4): (+ve) control: high fat diet and high fructose drinking (HF and HFr), Group (5): fed on HF and HFr contained wheat germ powder 20 % , Group (6): fed on HF and HFr and received wheat germ oil (1.5 ml / kg.bw /day) orally during the experimental period (6 weeks). Results showed wheat germ is high content of nutrients .The group fed HF and HFr showed significantly higher level of blood glucose, serum TG ,TC, LDL-c , VLDL-c , AST , ALT, ALP , creatinine, uric acid ,TNF α, leptin and  resistin and decrease in serum HDL-c , GSH  and CAT as compared to (-ve) control . While the groups fed high fat and high fructose diet containing WG and received WGO showed significant decrease in blood glucose, serum lipid profile, liver and kidney functions, TNF-α , leptin and  resistin while increasing the (GSH)  and (CAT) as compared to (+ve) control. From obtained results it can be recommend that consumption of wheat germ powder and oil may be beneficial for those which suffering from high glucose, triglycerides , total cholesterol diseases and can decrease the inflammatory response.