This research was carried out to study the impact of the traditional grilling process on the nutritional value and fatty acids composition of the most common Egyptian fish (Tilapia, Mullet and Sardine). The obtained results showed a decrease in moisture, ash and oil in grilled fish as a result of grilling process, where crude oil decreased from 22.14% to 11.40% (based on dry weight) in Mullet fish. While, crude protein increased from 69.04% to 86.71% (based on dry weight) in Mullet fish, too. As for fatty acids composition, decrease percentage of saturated fatty acids were 4.25% and 2.35% for Sardine and Tilapia, respectively, while this percentage increased in Mullet fish by 6.25% of saturated fatty acids. Also, monounsaturated fatty acids percentage decreased in Sardine and Mullet fish by 3.84% and 11.72%, respectively. Polyunsaturated fatty acids increased in all types of fish by various percentages. Total unsaturated fatty acids/ total saturated fatty acids ratio of fish oils increased in both Sardine and Tilapia, where the rise percentage were 9.76% and 4.6%, respectively, while decrease percentage of this ratio in Mullet fish was 9.55%. Results of this study has shown that the common Egyptian fish were very poor in polyunsaturated fatty acids content, especially the omega-3 (EPA and DHA). So, it is recommended to increase consumption of other types of fish which are rich in these fatty acids.