The effect of salinity stress on some physicochemical properties and minerals profile of Shami goats' milk produced under desert conditionwere investigated. Goats' milk samples were collected from a herd kept at Ras Sudr Research Station, DesertResearch Center, Egypt. Forty animals were divided equally into different four groups of feeding systems. Groups 1 and 2, fed on barseem hay, while groups 3 and 4, fed on salt tolerant fodder (alfalfa). Both of group1 and 3 were offered fresh drinking water, while group 2 and 4 were offered saline drinking water. Bulk samples were collected at the 1^st week of kidding after colostrums, and weekly up to 4 weeks.  Total milk yield, fat, protein, lactose, ash, total solids, pH and specific gratify were examined. Mineral concentrations in analyzed milk samples were calcium, magnesium, potassium and sodium (macroelement). In addition to boron, cobalt, chromium, copper, iron, manganese, molybdenum, selenium, and zinc as microelements. While, heavy metals were aluminum, arsenic, cadmium, lead, mercury, nickel, strontium and vanadium. The results show that milk yield and milk composition were not significantly (P<0.05) affected by the feeding systems expect lactose and ash, which were significantly (P<0.05) affected. Concentrations of all minerals were significantly (P<0.05) among the four studied groups. Calcium concentration in all groups was lower than normal level in goat milk; which might be due to contamination of goat's milk by lead from consumption contaminated feeding stuffs and/or water. Concentrations of molybdenum in the studied groups fed barseem hay (group 1 and 2) have lower than the groups fed alfalfa (group 3 and 4). The results show that an opposite relation between molybdenum and copper. Most of mineral variation could be due to the interaction effect of both saline tolerance plant and saline water on milk.