The present investigation was carried out to study the effect of stabilized rice bran oil (SRBO) on hypocholesterolemic activity of experimental rats, and also the effect of feeding with stabilization rice bran oil (SRBO) and blend oil on the growth and lipid parameters of serum and liver of rats. Fatty acids composition and unsaponifiable matter of stabilization rice bran oil and blend oil were determined, Results showed that, stabilization rice bran oil had a higher content of saturated fatty acids (SFA), polyunsaturated fatty acids (PUFA) than that of blend oil. stabilization Rice bran oil contained relatively higher concentration of compesterol, stigmasterol, b-sitoisterol, cycloartanol, cycloartenol 24-Methylene cycloartanol and oryzanol compared to the blend oil. The serum total and LDL-cholesterol level of rats that maintained on stabilization  rice bran oil diet was significantly lower than those fed on blend oil diet. HDL-cholesterol showed a tendency to be higher. Liver lipids of rats fed on stabilization rice bran oil were also markedly lower than their blend oil fed counterparts. Finally, it can be concluded that, using stabilization rice bran oil had the pronounced effects for lowering cholesterol levels of the blood in experimental rats. The cholesterol lowering ability stabilization of rice bran oil appears to be due to unsaponifiable matter  and a higher content of polyunsaturated fatty acids.