This study aimed to determine protective effect ginger extract and cactus saguaro extract against cancer cells. The current study has been on some  analysis for both Ginger extract and Cactus Saguaro were carried out. Results showed Moisture content ranged between 91:92% and Protein were 34.1 and 35.5 respectively for ginger and cactus. Total phenol, Total flavonoids, DPPH (radical scavenging activity) were also determined. Total phenol were 43.36 and 133.98 respectively. Results of Total flavonoids was ranged from 33.64 and 27.15 for ginger and cactus while ginger exhibited high amount DPPH was 36.55% and 45.21% ginger and cactus .  Cancer cells have been treated with different concentrations (6.25, 12.5, 25, 50 and 100 µg/ ml  ) from plants extracts and IC50  ) The  inhibition concentration) was calculated. The anticancer activity of ginger and cacti saguaro against human liver HEPG-2, breast MCF-7 and colon HCT116  cancer cells . So we recommend that using the extracts of both of ginger and cactus  them as natural components used in the treatment of cancer.