The aim of this work was to study the effect of feeding the experimental rats with Domiati cheese during storage on their histopathological alterations. To achieve this purpose, forty-two healthy rats were divided into three groups each of 12 rats. Each group fed daily one of the following diets for 120 days. Control rats fed on basal diet and water without any additives. Group (1) fed on control diet + 30% domiati cheese stored at room temperature, group (2) on control diet + 30% Domiati cheese stored in the refrigerator.At the end of the experiment; rats were sacrificed to obtain the livers, kidneys and examined for the histological examination. The microscopic examination of rats fed on Domiati cheese stored at room temperature and in the refrigerator showed histological changes in liver, kidney and testes tissues, compared to the control. These histological changes might be attributed to the high concentration of biogenic amines in the studied domiati cheese.