38712

Antihypertensive Effect of Novel Functional Fermented Milk in Induced High Blood Pressure Rats

Article

Last updated: 04 Jan 2025

Subjects

-

Tags

-

Abstract

The effect of functional fermented milk rich in bioactive peptides on blood pressure, lipid profile, antioxidant status and some organ's in hypertensive-induced rats was studied. Functional fermented milk produced from skimmed milk fortified with 2% SMP:WPC (1:1) and partially proteolyzed by trypsin (2.5 mg/100 g milk for 20 min) before fermintation by using mixed starter culture of Lb. rhamnosus B-1445, O-114, YC-X11 and Lb. helveticusLh-B 02 with a 3:2:1:1 ratio, respectively. The main obtained results showed that the daily administration of functional fermented milk (group 4) for 4 weeks lowered the systolic blood pressure (SBP) and diastolic blood pressure (DBP) by 43 and 9 mmHg, respectively compared with a  negative control group which administered saline (group 1). Plasma triglycerides, total cholesterol, atherogenic index and cardiac risk factor reduced in group 4 compared to group 1, while low-density lipoprotein, high-density lipoprotein, antithrombotic activity and antioxidant markers did not differ significantly among all groups. Histologically, there were no significant changes in the liver, kidney, heart and aorta tissues of rats in groups 1 and 4.  In contrast, there were histopathological changes in these tissues of rats in group 2 which received daily 2 mg captopril /100 g BW.

DOI

10.21608/jfds.2017.38712

Authors

First Name

Alaa

Last Name

Abd El-Fattah

MiddleName

M.

Affiliation

Dairy Science Department, Faculty of Agriculture, Cairo University, Giza, Egypt

Email

-

City

-

Orcid

-

First Name

Sally

Last Name

Sakr

MiddleName

S.

Affiliation

Dairy Science Department, Faculty of Agriculture, Cairo University, Giza, Egypt

Email

-

City

-

Orcid

-

First Name

Samia

Last Name

El-Dieb

MiddleName

M.

Affiliation

Dairy Science Department, Faculty of Agriculture, Cairo University, Giza, Egypt

Email

-

City

-

Orcid

-

First Name

H.

Last Name

Elkashef

MiddleName

A.

Affiliation

Dairy Science Department, Faculty of Agriculture, Cairo University, Giza, Egypt

Email

-

City

-

Orcid

-

Volume

8

Article Issue

7

Related Issue

6224

Issue Date

2017-07-01

Receive Date

2019-07-03

Publish Date

2017-07-01

Page Start

279

Page End

286

Print ISSN

2090-3650

Online ISSN

2090-3731

Link

https://jfds.journals.ekb.eg/article_38712.html

Detail API

https://jfds.journals.ekb.eg/service?article_code=38712

Order

4

Type

Original Article

Type Code

886

Publication Type

Journal

Publication Title

Journal of Food and Dairy Sciences

Publication Link

https://jfds.journals.ekb.eg/

MainTitle

Antihypertensive Effect of Novel Functional Fermented Milk in Induced High Blood Pressure Rats

Details

Type

Article

Created At

22 Jan 2023