Two field experiment were carried out at Ismailia Agricultural Research Farm Station located at 30º  35´ 41.901˝ N  for Latitude and 32º  16´ 45.834˝ E  for Longitude, Egypt, during  two successive summer seasons of 2011 and 2012 to investigate the effect of irrigation water intervals (6, 9 and 12 days), compost rates (0, 5 and 7 ton/fed) and bacterial inoculation (mixture of Serratia sp., B. polymyxa and Ps. fluorescens) on sesame productivity "variety Shandaweel 3" grown in sandy soil using sprinkler irrigation system. The experiments were laid out in a split-split plot design with three irrigation intervals as main plots and the three compost rates as sub-plots, while inoculation treatments randomly allotted in sub-sub plots. All sesame yield and its attributes was highly significant affected by theduration of irrigation intervals and there was an inverse relationship between increasing the length of irrigation intervals and the studied yield characters. Irrigation at 6 day interval produced the highest values of sesame yield and yield attributes compared to other water regimes. Also, data exerted that the rate of promotion in the studied sesame yield and its attributes increased gradually as the rate of compost manuring increased. Sesame yield achieved the highest productivity as a result of soil manuring with 7 ton compost/fed followed by 5 ton compost/fed. On the other hand, inoculation with mixture of tested rhizobacteria exerted a salient superiority in values of sesame yield and its attributes relative to uninoculated treatment. The interaction effect among irrigation water intervals, compost rates and bacterial inoculation were significant on all estimated traits, except, plant height, height of first capsule, 1000-seed weight and oil%. Furthermore, oil yield/fed was positively and highly correlated with all estimated traits. As a results of this study indicated that obtaining the highest sesame seed and oil yields/fed occurred when the crop was irrigated interval as narrow as possible up to 6 days interval along with inclusion of 7 ton compost/fed and rhizobacterial inoculation.