A field experiments was conducted at sakha  Agriculture Res. station to study the role of integrated system management of bio-organic fertilizers ( compost and compost tea) supplemented with selective strains of plant growth promoting rhizobacteria (PGPR) in combination with different levels of mineral fertilization, for enhancing protection of tomato plants against cucumber mosaic virus (CMV). In this study split plot design was applied where the main plots were randomly infected with or without viral infection, while the sub main plots were assigned by treated with bio-organic fertilizers and different levels of mineral fertilizers. Measurements of plant growth parameters including plants morphology (length and diameter of Fruits) ,of tomato yield and its chemical components (T.S.S, acidity , N₂, P₂O₅ and osmotic pressure ) were examined, as well as the activities of Peroxidase and polypheyloxidase enzymes were reported. Cucumber Mosaic Virus ( CMV) was isolated  From naturally infected tomato plants and identified according the recommended methods. Optained the results could be summarized in the following points:  1-     Plants without viral infection showed significant improvements of all the tested parameters due application of enriched bio-fertilizers individually or in combination with mineral fertilizers. Plots that received 6.7 kg compost + 60% N₂ + Compost tea was the best and showed superiority as compared with other treatments. 2-    Plant infected with virus, showed considerable reduction loss in all the tested parameters as result of the viral disease as compared with healthy plants that not infected with (CMV). Although diseased plant showed less values but it was higher than the unfertilized 3-    Plants infected with CMV and fertilized with bio.organic fertilizers (compost and compost tea ) and mineral fertilizers showed a clear  recovery in all the tested growth parameters and disease severity was reduced as compared with infertilized ones. 4-    As for example , the  calculated data of the percentage changes of tomato yield
(treatment received 6.7kg compost and 60% N and with compost tea sprayed)showed an increase of 19% of healthy plants as compared with respective control (2539.5and 2129.5 kg/ fed.),loss of 48.7% due to viral infection (2129.5 and 1123kg/fed) and clear recovery of about 25.8% in diseased plants due to fertilization treatments (1123.25 and 1413.6kg/fed) . 5-    The beneficial effects of the used treatment were extended to increase the activity of peroxidase and polyphenoloxidase enzymes in comparison with control plants. Data obtained clearly showed that application of suggested biofeitilizers increased the defensive capacity of tomato plants against the harmful effect of CMV.