48450

ANTIOXIDANT AND HEPATOPROTECTIVE EFFECT OF Cinnamomum zeylanicum OIL AGAINST PARACETAMOL INDUCED HEPATOTOXICITY IN MALE RATE.

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Last updated: 04 Jan 2025

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Abstract

The main objective of this study is a trial to investigate the efficiency of cinnamomum zeylanicum (cinnamon) oil against paracetamol induced hepatotoxicity in male rats. The bark cinnamon was hydrodistilled using Clevenger,s apparatus to yield essential oil 2.3%.Total phenolic compounds and scavenging radical effect on 2, 2-diphenylpicrylhydrazyl (DPPH) were investigated. Gas chromatographic- mass spectroscopy fractionated cinnamon bark volatile oil to six components accounting for 100% of total amount. Cinnamaldehyde was found as the major component 68.01% followed by Eugenol 11.47, Cinnamyl alcohol 6.52% , α- murolene 5.24%, δ- cadinen 4.41% and Methyl eugenol 4.35%. Biological experiment was carried out for eight weeks. Results revealed that liver marker enzymes alanine transaminase (ALT) aspartate transaminase (AST), alkaline phosphatase (ALP) were increased. On the other hand serumtotal protein and serum albumin were decreased as well as, lipid profile of total lipids (TL), triglycerides (TAG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) were increased  and high density lipoprotein cholesterol (HDL-C)was decreased in paracetamol treated rats(group2). Lipid peroxidation malondialdehyde (MDA) was increased in liver tissue of rats treated with paracetamol, while activities of glutathione peroxidase(Gpx) and Glutathione-S-transferase (GST) were decreased. Cinnamon oil both dose and silymarin showed remarkable hepatoprotective and antioxidant activity against paracetamol induced hepatotoxicity as judged from the serum marker enzymes and antioxidant in liver tissue.

DOI

10.21608/jacb.2015.48450

Keywords

Cinnamomum zeylanicum, cinnamon oil, phenolic, Antioxidant, hepatoprotective , paracetamol

Authors

First Name

A. E. A.

Last Name

El-Hadary

MiddleName

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Affiliation

Biochemistry Department, Faculty of Agriculture, Benha University, Egypt

Email

elhadary.a@fagr.bu.edu.eg

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Orcid

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Volume

6

Article Issue

10

Related Issue

7534

Issue Date

2015-10-01

Receive Date

2015-10-05

Publish Date

2015-10-01

Page Start

407

Page End

418

Print ISSN

2090-3626

Online ISSN

2090-3707

Link

https://jacb.journals.ekb.eg/article_48450.html

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https://jacb.journals.ekb.eg/service?article_code=48450

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2

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Original Article

Type Code

883

Publication Type

Journal

Publication Title

Journal of Agricultural Chemistry and Biotechnology

Publication Link

https://jacb.journals.ekb.eg/

MainTitle

ANTIOXIDANT AND HEPATOPROTECTIVE EFFECT OF Cinnamomum zeylanicum OIL AGAINST PARACETAMOL INDUCED HEPATOTOXICITY IN MALE RATE.

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Article

Created At

22 Jan 2023