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144108

MEASUREMENT OF SERUM BIOCHEMICAL LIVER PARAMETERS AND HCV RNA LEVELS FOR DETECTION THE SEVERITY OF HEPATITIS C VIRUS-ASSOCIATED HEPATOCELLULAR CARCINOMA

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Last updated: 04 Jan 2025

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Abstract

Hepatitis C virus (HCV) is one of the leading causes of chronic liver disease. Hepatocellular carcinoma (HCC) is a major complication associated with HCV virus infection, with significant mortality and morbidity rates. This study aimed to measure biochemical liver parameters and HCV RNA levels for detection the severity of hepatitis C virus- associated hepatocellular carcinoma. The study was conducted on 100 patients, with ages ranging from 36 to 68 years and patients grouped into four groups. The 1 st group served as control group (n= 25),the second group (n=25): Hepatitis C Virus, the third group (n=25): HCV-associated HCC and the fourth group (n=25): After HCC removal and tumor resection. Serum samples were collected from the studied patients. Liver function enzymes (ALT, AST, Alkaline phosphatase) and another function parameters (Albumin and Total bilirubin) were tested to all patients of the studied groups. The results showed that hepatitis C Virus, HCV-associated HCC, and after HCC removal groups had an increase in liver function enzymes, decrease in albumin levels, and an increase in total bilirubin levels which indicate damage in the liver. Viral loads indicated in males infected higher than in females and significantly increased in HCV patients, and a highly significant increase in HCV associated HCC patients. Conclusively, Hepatitis C Virus, HCV-associated HCC, and After HCC removal groups had an increase in liver function enzymes, decrease in albumin levels, and an increase in total bilirubin levels which indicate damage in the liver. Viral loads indicated in males infected higher than females are significantly increased in HCV patients, and a highly significant increase in HCV associated HCC patients.  

DOI

10.21608/jpd.2021.144108

Keywords

Liver parameters, HCV, Hepatocellular carcinoma, HCC

Authors

First Name

Mohamed

Last Name

Ebeid

MiddleName

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Affiliation

Biochemistry and Molecular biology Department, Genetic Engineering and Biotechnology Research Institute, Sadat City University, Egypt.

Email

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City

Biotechnology Research Institute, Sadat City University, Egypt.

Orcid

-

First Name

Ibrahim

Last Name

El Sayed

MiddleName

-

Affiliation

Biochemistry, Faculty of Science , Kafr El-Sheikh University, Egypt

Email

-

City

Faculty of Science , Kafr El-Sheikh University, Egypt

Orcid

-

First Name

Ismail

Last Name

Hegzy

MiddleName

-

Affiliation

Biochemistry Department, Faculty of Medicine, Al-Azhar University, Egypt.

Email

-

City

Faculty of Medicine, Al-Azhar University, Egypt

Orcid

-

First Name

Maha

Last Name

El Mansy

MiddleName

-

Affiliation

Clinical and Chemical Pathology, Haematology Department, Theodor Bilharz Research Institute, Egypt

Email

-

City

Theodor Bilharz Research Institute, Egypt

Orcid

-

First Name

Samah

Last Name

Mamdouh

MiddleName

-

Affiliation

Biochemistry and molecular biology, Theodor Bilharz Research Institute, Egypt.

Email

-

City

Theodor Bilharz Research Institute, Egypt.

Orcid

-

First Name

Fatma

Last Name

Khorshed

MiddleName

-

Affiliation

Biochemistry and molecular biology, Theodor Bilharz Research Institute, Egypt.

Email

-

City

Theodor Bilharz Research Institute, Egypt.

Orcid

-

First Name

Maysa

Last Name

Abd Rabou

MiddleName

-

Affiliation

Medical Laboratories, Faculty of Applied Medical Sciences, October 6 University, Egypt.

Email

-

City

Faculty of Applied Medical Sciences, October 6 University, Egypt.

Orcid

-

Volume

26

Article Issue

1

Related Issue

20759

Issue Date

2021-01-01

Receive Date

2020-11-14

Publish Date

2021-01-01

Page Start

97

Page End

106

Print ISSN

1110-2543

Online ISSN

2682-3322

Article File

JPD_Volume 26_Issue 1_Pages 97-106.pdf

PDF . 553.3kB

Link

https://jpd.journals.ekb.eg/article_144108.html

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https://jpd.journals.ekb.eg/service?article_code=144108

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5

Type

Original Article

Type Code

867

Publication Type

Journal

Publication Title

Journal of Productivity and Development

Publication Link

https://jpd.journals.ekb.eg/

MainTitle

MEASUREMENT OF SERUM BIOCHEMICAL LIVER PARAMETERS AND HCV RNA LEVELS FOR DETECTION THE SEVERITY OF HEPATITIS C VIRUS-ASSOCIATED HEPATOCELLULAR CARCINOMA

Details

Type

Article

Created At

22 Jan 2023