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188994

SYNTHESIS AND ANTIBACTERIAL EVALUATION OF CERTAIN 1,2,4- TRIAZOLE AND THIAZOLID INONE DERIVATIVES

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Last updated: 22 Jan 2023

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Abstract

The synthesis of certain 3 -  (4- chloro - 3,5 - đimethyl - phenoxy ) methyl  4-alkyl or aryl -5 mercapto - 1,2,4 - triazoles ( 5a - e) is described. The preparation of these triazoles was achieved by the cyclization of the corresponding thiosemicarbazides (Af- i) using piperidine in refluxing ethanol. Also , series of thioethers (6a,b) and (7a-g) were obtained by reacting (5) with different halo- compounds .The thiaz olidinone derivatives (8 a - d ) were prepared by reacting (4f - j) with ethyl bromoacetate .The new compounds were proved by elemental analysis, ir and 1H- nmr. The antibacterial activity was carried out for eight representative compounds .

DOI

10.21608/zjps.1993.188994

Authors

First Name

Awatef

Last Name

Farag

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, faculty of Pharmacy, Cairo University, Cairo, Egypt

Email

awatef.farag@yahoo.com

City

-

Orcid

-

First Name

Safinaz

Last Name

Abbas

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, faculty of Pharmacy, Cairo University, Cairo, Egypt

Email

safinaz.abbas@yahoo.com

City

-

Orcid

-

First Name

Anwar

Last Name

Mikhael

MiddleName

-

Affiliation

BACTERIOLOGY DEPARTMENT, FACULTY OF MEDICINE, CAIRO UNIVERSITY.

Email

anwar.mikhael@yahoo.com

City

-

Orcid

-

First Name

Mona

Last Name

Abdel Messeh

MiddleName

-

Affiliation

BACTERIOLOGY DEPARTMENT, FACULTY OF MEDICINE, CAIRO UNIVERSITY.

Email

mona.abdel-messeh@yahoo.com

City

-

Orcid

-

Volume

2

Article Issue

1

Related Issue

24775

Issue Date

1993-06-01

Receive Date

1993-03-17

Publish Date

1993-06-01

Page Start

108

Page End

119

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 2_Issue 1_Pages 108-119.pdf

PDF . 4.7MB

Link

https://zjps.journals.ekb.eg/article_188994.html

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https://zjps.journals.ekb.eg/service?article_code=188994

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11

Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

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Article

Created At

22 Jan 2023