This study was carried out in Sharkia Governorate, Egypt to compare between biochemical constituents contents, enzymes activities and elements concentrations in shell of two species of most dangerous land snail in Egypt (Monacha cartusiana and Eobania vermiculata). The obtained results showed that M. cartusiana hemolymph was charactarizd with high concentration of carbohydrates (2798.33 ± 59.18ug/ml), total lipids (657.00±23.28ug/ml), total protein (25.05 ±0.47 mg/ml), malondialdehyde (MDA) (11.43±0.33 n mol./ml) and urea content (138.33±7.04 mg/100 ml). Also enzymes activities [Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Glutathione S-transferase (GST) and phenol oxidase)] were higher in the hymolymph of M. cartusiana than those in hemolymph of E. vermiculata. Shell contents of elements in E.vermiculata was contained a higher concentration of P (232.14 ± 4.04 ppm), Mg (566.25±3.46 ppm), Fe (487.82 ± 6.77 ppm), Cu (18.94 ± 2.30 ppm), K (1202.50 ± 4.04 ppm), Na (1230.25±5.77 ppm) and Zn (5.98 ± 1.15 ppm) than those of M. cartusiana, while shell of M. cartusiana was characterized with higher content of Ca(503925.00±14.43 ppm) than shell of E. vermiculata.