Cancer is a big health problem with high morbidity and mortality and possess both economic and psychological challenges. The aim of the present study is to evaluate methanolic 70% melia azedarch and moringa extracts for their anticancer activities using two cancer cell lines: hepatocellular carcinoma cell line (HePG2) and breast carcinoma cells lines (MCF7). The results showed that Melia azedarch methanolic 70% extract exhibited a pronounced cytotoxic effect and was found to possess a very potent inhibitory activities against hepatocellular carcinoma cell line (HePG2) and breast carcinoma cells lines (MCF7). In vitro studies of methanolic 70% of Moringa olefiera extract showed no activity on both cancer cell lines hepatocellular carcinoma cell line (HePG2) and breast car cinoma cells line (MCF 7).