Squash plants were sprayed with Vertimec (abamectin) 1.8% EC and Ritreap (cyflufenamid) 5% EW at the rate of 40 cm3 / 100 L water and 20 cm3 / 100 L water, respectively during the summer season of 2016. Samples leaves, fruits and soil were collected at 2 hrs to 12 days after application and QuEChERS method was used for extraction and clean-up and analyzed using HPLC and gas chromatography for abamectin and cyflufenamid, respectively. Results revealed that, the initial amounts of each pesticide in leaves were much higher than those in squash fruits. Loss percentages in residues were higher in squash fruits than leaves. The residues amounts of the two tested pesticides were more greatly detected in peel than that the pulp. Data also show that washing and peeling of squash fruits resulted in removing reasonable amounts of residues especially with the first three samples. The rate of dissipation in abamectin was more than in cyflufenamid and the consumable safety time was 6 days after application of these pesticides on Squash fruits.