Two field experiments were conducted during two successive seasons of 2014/2015 and 2015/2016 at Vegetable Experimental Research Farm in Kaha, Kaliobia Governorate to study the effect of application method of safety compounds on growth and productivity of globe artichoke cv. "Concerto" used treatments included three different application method; i.e., soaking 20 min., spraying 6 times started after 70 days from planting date and repeated every 15 days through the growth season and soaking plus spraying in  seven different safety compounds; i.e., Amino power (source of free amino acids) 0.5 cm³/l, Fruiting (source of gibberellins) 0.5 cm³/l, Mega humic acid (source of humic acid) 0.25 g/l, Cytojeep (source of gibberellins plus free amino acids) 0.5 cm³/l, Chitosan 1% and Garlic extract 50 cm³/l as well as tap water (control). A split plot design with four replicates was used in this experiment. Main plots were application method and sub-plots were safety compounds. The obtained results revealed that spraying Mega humic acid or soaking plus spraying significantly produced the highest leaves number/ plant, plant height, produced yield (early, late and total) expressed as heads weight / plant, head and edible part weight (early and late yield), dry matter percentage in late yield as well as the lowest total phenols in early yield comparing with the control. On the other hand, using Cytojeep significantly produced the highest offshoots number / plant and the least number of days to the anthesis. Also, spraying Fruiting significantly increased inuline percentage in early and late yield and decreased the fibers contents in late yield.