Pomegranate, which is known as Rumman in Arab region, has been used in traditional medicine in many countries for its beneficial health effects to treatment various illnesses as dysentery, diarrhea, acidosis and many other diseases. Water extract of pomegranate has been used to treatment diarrhea in Syria for long time, and dried peels are kept in almost every house in Damascus for this purpose. However, the contents of water extract of local pomegranate peel, which is used in traditional method to cure diarrhea, and the in vitro  antibacterial activity are not investigated. In the current study we tried to investigate the total phenolic contents as indicator of beneficial compounds in the water extract of pomegranate peels obtained from the two varieties (sweet and sour pomegranate), and the antibacterial activity of these extracts against two foodborne pathogenic bacteria namely Bacillus cereus and Salmonella typhi, which are responsible for diarrhea syndromes.