Frictional pressure loss for flow of Sodium Carboxymethyl Cellulose (SCMC) aqueous solutions in piping system has been experimentally, investigated. Pipes of inner diameters range from 6 to 17.5 mm, were used. SCMC aqueous solutions have been found to behave as pseudoplastic fluids. Smooth and rough pipes have been used for SCMC concentration ranges from 0.03 to 1.1 wt.%. It has been found that the pressure drop-flow rate diagram for pipes was similar to that of Newtonian fluids, with different consistency equation and transient Reynolds number. As concentration increases, the pressure loss increases, apperciably in the laminar region than in the turbulent one.