The most prominent over-the-counter antipyretic-analgesic drug is paracetamol (APAP). This study attempted to examine whether allicin (AC) and/or omega-3 (O3FA) could protect rats from the liver damage induced by APAP. Rats were randomly distributed to seven groups: Control (saline), AC (10 mg/kg, PO), O3FA (100 mg/kg, PO), APAP (1000 mg/kg, PO single dose on 27th day), AC+APAP, O3FA+APAP, and AC+O3FA+APAP group. APAP had a significant negative impact on haematological and serum biochemical markers as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and Alkaline phosphatase (ALP) activity, as well as cholesterol and triglycerides activity in the serum, while total protein and albumin levels were reduced compared to control. These findings strongly suggested that hepatic injury occurred in response to the APAP exposure. Histopathological examinations of liver sections confirmed the hepatoprotective potential. Hydropic degeneration of the hepatocytes, necrosis and hepatic tissues degeneration were evident after APAP treatment. Allicin and/or omega 3 treatment enhance hepatic tissue architecture after treatment. Thus, pre-treatment with AC and O3FA alone or in combination was effective to reduce hepatic injury in APAP-intoxicated rats, probably as a result of its high antioxidant content.