Total ninety random meat samples of fresh fish of Nile tilapia, Bagrus bayad and Clarias gariepinus (thirty of each) were collected from different Egyptian fish markets to be examined for their chemical quality indices to determine their fitness for human consumption. The results showed that the pH value was (6.32±0.01, 6.38±0.02 and 6.29±0.02), TVB-N (mg/100) was (14.54± 0.51, 12.71± 0.43 and 16.76± 0.46), TBA (mg malonaldyde/kg) was (0.82± 0.05, 0.57 ± 0.03 and 0.91± 0.06) and TMA (mg/100) was (6.19± 0.23, 5.49± 0.21 and 6.75± 0.19) in the examined samples of Nile tilapia, Bagrus bayad and Clarias gariepinus, respectively. So, it was appeared that the Clarias gariepinus samples were higher in their pH, TVB-N, TMA, TBA values than other examined samples. All examined samples were fit for human consumption except one Clarias gariepinus sample (3.33%) was unfit due to increasing its pH value than the limit of acceptability. This study shows superiority of Bagrus bayad were more than Nile tilapia followed by Clarias gariepinus samples in their chemical quality indices. So, we recommend proper handling of fish from catching till eating to preserve their human consumption fitness.