Objective: The present study was design to determine the biochemical changes effect of thyme, ginger and BOL as growth on male New-Zealand rabbits. Methods: Twenty four white New-Zealand male rabbits were selected at the age from 6-8 weeks old with an average body weight of 0.600 - 0.750 kg were used in the experimental investigation of this study. The rabbits were fed on a basal feed diet throughout the course of the experiment in the form of concentrated feed diet composed. All rabbits were randomly assigned into four equal groups (6 animals per each group). The biochemical analysis estimated total protein, lipid profile include: cholesterol and triglyceride, albumin, creatinine, blood serum aspartate aminotransferase (AST), alkaline phosphatase (ALP), oxidative stress marker such as glutathione (GSH) concentration, cytokine (IL-6), testosterone level and growth hormone were determine by using biolabo commercial kits with spectrophotometer, ELISA and radioimmunoassay machine at the biochemistry laboratory. Results: After one month treatments, no significance difference was found between the rabbits groups in initial body weight in the 1st administration compared 2nd administration. There was increasing of ALP and AST with ginger and increase of ALP with thyme even their positive effect on the other concerned parameters in our study. Ginger increase level of serum IL-6 levels and GSH concentrations, while thyme decrease its level in serum. Although Thyme supplementation group improved the growth performance and feed efficiency of rabbits in comparison to ginger supplementation group and control group.