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91586

Zinc nanoparticles coated with Gallic acid potentially ameliorate hepatocellular carcinoma-induced in rats

Article

Last updated: 24 Dec 2024

Subjects

-

Tags

Biochemistry

Abstract

Materials on the nanoscale are increasingly being targeted to cancer cells with great specificity through both active and passive targeting. In the current study, the potential therapeutic effect of the newly synthesized Zinc nanoparticles coated with Gallic acid (Zn-GANPs) against hepatocellular carcinoma (HCC) - induced in rats were evaluated. Forty rats were divided into four equal groups, group 1: normal control, group 2: received diethylnitrosamine (DEN) (20 mg/Kg b.wt, 5 times per week for 8 weeks), group 3: received Zn-GANPs (20 mg/kg b.wt/day, i.p) from the onset of the 9th week till the end of the experiment (13 weeks), group 4: DEN + Zn-GANPs treated group: Rats were received DEN as group (2) and subsequently treated with Zn-GANPs as group (3) till the end of the experiment (13 weeks).Blood samples and liver tissue specimens were collected for biochemical analysis and histopathological examination. The obtained results revealed that in HCC-induced rats serum aspartate aminotransferase (AST) activity, total bilirubin and creatinine levels were increased, while total protein, albumin concentrations and liver catalase activity were significantly decreased as compared with control normal group. Administration of Zn-GANPs to HCC-induced rats non significantly reduced serum AST activity, total bilirubin and creatinine concentrations. However, serum total protein and albumin levels were non significantly increase and liver catalase activity was markedly increased in Zn-GANPs treated liver cancer group. Ameliorative effect of Zn-GANPs was appreciated with the histopathological alterations observed in DEN groups. These result suggesting the efficacy of Zn-GaNPs administration as an anti-HCC.

DOI

10.21608/bvmj.2019.17228.1097

Keywords

HCC, Zn-GANPs, Cytotoxicity, Liver function tests, HepG2 cell line

Authors

First Name

Faten

Last Name

Shoker

MiddleName

Elkenany

Affiliation

Biochemistry Department, Faculty of Vet. Med., Benha University, Egypt.

Email

fatenelkenanyshoker644@gmail.com

City

kafrhassan samanoud

Orcid

0009-0002-4774-3031

First Name

Omayma

Last Name

AbouZaid

MiddleName

Ragab

Affiliation

Department of Biochemistry, Faculty of Veterinary Medicine, Moshtohor, Benha University.

Email

omayma_ragab@yahoo.com

City

-

Orcid

-

First Name

Sawsan

Last Name

EL-sonbaty

MiddleName

Mohammed

Affiliation

Radiation Microbiology Department, National Centre for Radiation Research and Technology. Egypt.

Email

sawsansonbaty@yahoo.com

City

-

Orcid

-

Volume

37

Article Issue

1

Related Issue

8030

Issue Date

2019-09-01

Receive Date

2019-09-24

Publish Date

2019-09-01

Page Start

216

Page End

222

Print ISSN

1110-6581

Online ISSN

2974-4806

Link

https://bvmj.journals.ekb.eg/article_91586.html

Detail API

https://bvmj.journals.ekb.eg/service?article_code=91586

Order

43

Type

Original Article

Type Code

812

Publication Type

Journal

Publication Title

Benha Veterinary Medical Journal

Publication Link

https://bvmj.journals.ekb.eg/

MainTitle

Zinc nanoparticles coated with Gallic acid potentially ameliorate hepatocellular carcinoma-induced in rats

Details

Type

Article

Created At

22 Jan 2023