This study was made to evaluate the therapeutic efficacy of medicinal herbal mixture powder (Cinnamon, Rhubarb, Gentian, Nux Vomica, Nutmeg, Ginger and Boldo) in field cases of sheep with ruminal acidosis. Ten sheep suffered from acidosis were used to achieve this goal. In addition ten apparently healthy sheep were used as a control. The acidotic sheep showed anorexia, weakness, dullness, pasty feces, tympany and reluctance to move.There was significant increase (p<0.05) in respiratory rate and pulse rate, while body temperature and ruminal movement were significantly decreased (p<0.05). There were significant increase (p<0.05) in Hb content, PCV%, RBCs, WBCs, granulocyte, lymphocyte and monocyte in acidotic sheep than healthy one. Biochemically, there was significant decrease (p<0.05) in Na, Cl, Mg, Ca, SOD, catalase, albumin and total protein; whereas significant increase (p<0.05) in K, P, AST, ALT, GGT, ALP, urea, creatinine, MDA, CRP, histamine and vitamin B12 were detected in acidotic sheep. The clinical, hematological, biochemical and ruminal parameters were significantly changed toward the control values after treatment with medicinal herbal mixture. Therefore, these herbal mixtures are recommended for treatment of sheep suffered from acidosis.