The aim of this study was to compare the effect of different treatment in cat models of induced nutritional secondary hyperparathyroidism (NSHPT) by using chicken's eggs hell compared to other conventional treatments. The NSHPT was induced experimentally in 20 rapidly growing kittens by feeding a diet consisted of only beef heart meat (low Ca-high P) for 9weeks. The clinical signs of NSHPT in kittens included disturbance in locomotion manifested by reluctance to move, posterior lameness, and uncoordinated gait. The diseased kittens were divided into four equal groups (n=5), each group was treated with a different protocol. Treatment of affected kittens was achieved by eggshell (G4) that was compared to three treatment protocols including combined Ca- vitamin D injection. (G1), oral Ca alone (G2) and oral Ca, Mg, and Zn (G3). The clinical symptoms and biochemical analysis were monitored at day 1, 3, 5 and 7 after treatment.  The PTH and 1.25 (OH) 2 Vit.D3were gradually reduced starting from the 1st day post treatment in eggshell treated group compared to other treatment groups. The eggshell treatment induced changes in clinical signs and biochemical parameters that were comparable to the other three groups. Based on these results, it was suggested that feeding egg shell solution could be used as an economic source of Caasan alternative treatment for NSHPT in cats.