Proanthocyanidins, also known as condensed tannins, can prevent obesity induced oxidative stress damage in the liver. This study aimed to evaluate the protective effect of Proanthocyanidins on obesity induced oxidative stress and biochemical abnormalities in male rats. Forty -eight male albino rats were divided into three equal groups. Group I (control normal): rats received normal diet. Group II (Obesity): rats received high fat diet (HFD). Group III (Obesity+ Proanthocyanidins): rats received Proanthocyanidins (50 mg/kg.b.wt.) orally for two months after induction of obesity. The obtained results showed significant increase in serum insulin, lipids profile (total cholesterol and triacylglycerols) concentrations, liver L-MDA in addition to up regulation of leptin and Nuclear factor kappa B (NF-κB) gene expression level in liver tissues of obese rats. However, liver catalase activity and GSH concentration were markedly decreased. These results suggested that, Proanthocyanidins treatment exerts a protective effect on obesity by reduction of oxidative stress, inflammation and hyperlipidemia in rats through free radical scavenging and anti-inflammatory activities as well as
regenerating endogenous antioxidant defense system mechanisms.