Eighty random samples of fresh and salted fish represented by fresh Sardine and salted Sardine & fresh Mugil cephalus and salted Mugil cephalus (20 of each) were collected from various fish markets in Menoufia governorate, Egypt. The collected samples were examined for determination of their mercury and lead levels on the basis of wet weight (mg/kg). The mean values of mercury level in the examined samples were 0.98 ± 0.07 & 1.26 ± 0.13 for fresh and salted sardine fish and 0.69 ± 0.04 &1.59 ± 0.16 for fresh and salted Mugil cephalus, respectively. Accurately 50%, 65%, 40%, 80% of the examined samples of fresh sardine, salted sardine, fresh Mugil cephalus and salted Mugil cephalus were unaccepted according to E.O.S. The mean value for the lead levels mg/kg in the examined samples were 0.32 ± 0.03 & 0.49 ± 0.05 for fresh & salted sardine and 0.26 ± 0.02 & 0.65 ± 0.08 for fresh and salted Mugil cephalus, respectively. Accurately 35%, 45%, 30%, 65% of the examined samples of fresh & salted Sardine and fresh & salted Mugil cephalus were unaccepted according to E.O.S.