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44748

The potential anticancer effect of [Cadmium-N Acetyl cysteine] as novel drug therapy for mammary cancer induced by Di Methyl Benzene Anthanthrene in rats

Article

Last updated: 04 Jan 2025

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Subjects

-

Tags

Biochemistry

Abstract

The discovery of Cisplatin triggered the development of novel drugs containing other metals. Extremely diverse structural Chemistry and interaction of metal with ligand resulted in exploration of novel metal complexes with drug potential. The present work carried on 80 female rats which divided into four groups, after 12 weeks the mammary tumor appeared the possible anti-cancer effect of (Cadmium-N Acetyl Cysteine) which has been synthesized and study its effect on (Cd44, Cyclin D1, p21, caspase3, caspase 9 and cell cycle) were investigated on bearing solid mammary tumor induced by DMBA in rats

DOI

10.21608/bvmj.2018.44748

Keywords

Metal complex- CD44-Cyclin D1-Caspase-ligand

Authors

First Name

Omayma

Last Name

A.R. AbouZaid

MiddleName

-

Affiliation

Biochemistry Department, Faculty of Vet. Med. Moshtohor, Benha University, Egypt.

Email

-

City

-

Orcid

-

First Name

Eman

Last Name

Noaman

MiddleName

-

Affiliation

Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Egypt.

Email

-

City

-

Orcid

-

First Name

Shaimaa

Last Name

abdel-Ati

MiddleName

-

Affiliation

Biochemistry Department, Faculty of Vet. Med. Moshtohor, Benha University, Egypt.

Email

-

City

-

Orcid

-

First Name

Gehad

Last Name

Mohamed

MiddleName

Genidy

Affiliation

Professor of Inorganic Chemistry, Faculty of Science Cairo University.

Email

-

City

-

Orcid

-

Volume

34

Article Issue

3

Related Issue

6374

Issue Date

2018-08-01

Receive Date

2019-08-15

Publish Date

2018-08-01

Page Start

232

Page End

245

Print ISSN

1110-6581

Online ISSN

2974-4806

Article File

BVMJ_Volume 34_Issue 3_Pages 232-245.pdf

PDF . 493.0kB

Link

https://bvmj.journals.ekb.eg/article_44748.html

Detail API

https://bvmj.journals.ekb.eg/service?article_code=44748

Order

19

Type

Original Article

Type Code

812

Publication Type

Journal

Publication Title

Benha Veterinary Medical Journal

Publication Link

https://bvmj.journals.ekb.eg/

MainTitle

The potential anticancer effect of [Cadmium-N Acetyl cysteine] as novel drug therapy for mammary cancer induced by Di Methyl Benzene Anthanthrene in rats

Details

Type

Article

Created At

22 Jan 2023