Pomegranate (Pomg) fruit contains many phenolic compounds with high antioxidant activity, which may have useful health properties including flavonoids anthocyanins, flavonoids and hydrolysable tannins (punicalagin). The pomegranate peel includes tannins, gallagic acid ellagic acid and its esters of glucose and flavonoids. Oxidative stress is an imbalance between free radical production and the antioxidant defense system which could lead to lipid, protein and/or DNA alterations in this respect, the possibility exists that sucrose feeding facilitates oxidative damage. For the present study, the strong antioxidant activity of POMG on some antioxidant parameters in liver and heart of male rabbits exposed to high sucrose diet (HSD) induced oxidative stress, were investigated. Eighty (80) male rabbits at age of 4 weeks, weighting 500- 600 g. were used in this study. The rabbits were divided into four equal groups. 1) Control Normal group: kept on basal ration. 2) Stressed group (HSD): reared on the 25% sucrose concentration ration, daily for 4 months. 3) Pomegranate peel extract (PPE) group: reared on 25% pomegranate peel powder ration only, daily for 4 months. 4)Sucrose + PPE: kept on equal amounts of 25% sucrose and 25% PPE rations, daily for 4 months. Liver and heart samples were collected from all animal groups two times, after 2 and 4 months of experiment period. Levels of reduced glutathione (GSH) and activities of Catalase (CAT) and Glutathione-S-Transferase (GST) were determined in liver and heart tissues. Extent of oxidative stress was also assessed by liver and heart lipid peroxide L-Malondialdehyde (MDA) and Hydrogen peroxide H₂O₂. The obtained results revealed that, HSD supplementation exhibited a significant increase in: 1) Liver and heart MDA and H₂O₂ concentrations. PPE supplementation to stressed rabbits exhibited a significant decrease in the previously mentioned parameters. On contrast, HSD supplementation exhibited a significant decrease in liver and heart GSH, CAT and GST. Supplementation of PPE to stressed rabbits exhibited a significant increase in all mentioned parameters. From the obtained results, it could be concluded that, the potential of POMG as natural antioxidant act as a powerful agent against the harmful effects of sucrose induced oxidative stress.