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39641

Ameliorative Effects of Curcumin and Ginger on Hyperlipidemia – Induced Osmotic Fragility and Phospholipids Composition Changes of Erythrocytes in Albino Rats

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Last updated: 04 Jan 2025

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Physiology

Abstract

The present study was designed to investigate the erythrocytic changes caused by hyperlipidemia in rats and to evaluate the possible protective effects of curcumin and ginger supplementation. Forty male albino rats were assigned into four equal groups. Group I (control group), rats were fed basal diet. Group II (high-fat diet, HFD group), rats were fed HFD. Group III (curcumin supplemented HFD group), rats were fed HFD contain 0.2% curcumin. Group IV (ginger supplemented HFD group), rats were fed HFD contain 4% ginger. After 2 months, blood samples were collected from retroorbital venous plexus for determination of osmotic fragility of erythrocytes, membrane phospholipids composition and serum lipid profiles. The obtained results revealed that feeding HFD to rats significantly increased serum TC, TAG, LDL-C and phospholipid (phosphatidyl choline, phosphatidyl serine, phosphatidyl ethanolamine and phosphatidyl inositol) concentrations and significantly decreased hemolysis % at 0.4 and 0.5 % Na Cl concentrations as compared with control group. Whereas these changes ameliorated by dietary supplementation of curcumin and ginger as feeding HFD supplemented with 0.2% curcumin or 4% ginger significantly decreased TC, TAG, LDL-C and phospholipid concentrations and significantly increased hemolysis % at 0.4 and 0.5 % Na Cl concentrations as compared with high fat diet fed group. We concluded that supplementation with ginger and curcumin to HFD rats resulted in a significant decrease in serum lipid concentration, lowering membrane phospholipid and beneficially decreased mean cell fragility of erythrocytes thus restored the normality of erythrocyte fluidity in high fat diet fed rats

DOI

10.21608/bvmj.2018.39641

Keywords

hyperlipidemia, erythrocyte osmotic fragility, membrane phospholipids, curcumin and ginger

Authors

First Name

Shaimaa I.

Last Name

El-Barbary

MiddleName

-

Affiliation

Department of Physiology, Faculty of Veterinary Medicine, Benha University, Egypt

Email

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City

-

Orcid

-

First Name

Mohamed

Last Name

E. Azab

MiddleName

-

Affiliation

Department of Physiology, Faculty of Veterinary Medicine, Benha University, Egypt

Email

-

City

-

Orcid

-

First Name

Randa

Last Name

S. Ismail

MiddleName

-

Affiliation

Department of Physiology, Faculty of Veterinary Medicine, Benha University, Egypt

Email

-

City

-

Orcid

-

First Name

Abeer

Last Name

A. Nafeaa

MiddleName

-

Affiliation

Department of Physiology, Faculty of Veterinary Medicine, Benha University, Egypt

Email

-

City

-

Orcid

-

Volume

35

Article Issue

1

Related Issue

5726

Issue Date

2018-09-01

Receive Date

2019-07-08

Publish Date

2018-09-01

Page Start

327

Page End

341

Print ISSN

1110-6581

Article File

BVMJ_Volume 35_Issue 1_Pages 327-341.pdf

PDF . 268.2kB

Link

https://bvmj.journals.ekb.eg/article_39641.html

Detail API

https://bvmj.journals.ekb.eg/service?article_code=39641

Order

33

Type

Original Article

Type Code

812

Publication Type

Journal

Publication Title

Benha Veterinary Medical Journal

Publication Link

https://bvmj.journals.ekb.eg/

MainTitle

Ameliorative Effects of Curcumin and Ginger on Hyperlipidemia – Induced Osmotic Fragility and Phospholipids Composition Changes of Erythrocytes in Albino Rats

Details

Type

Article

Created At

22 Jan 2023