A total number of 80 Wister male rats, 9 -wk. old were taken, weighed and divided into four experimental groups to evaluate the oral toxicity induced by Deltamethrin (DLM) administration (0.87, 8.7 and 17.4 mg/kg B.W) for a period of 9 weeks on Iron homeostasis and inflammatory markers of Wister male rats. The results indicated that DLM was associated with a statistically significant elevated in levels of Interluken2(IL2), Interluken6(IL6),  Histamine, cortisol, Ammonia, Haptoglobulin, Transferrin and total iron binding capacity (TIBC), while decreased in Iron (Fe) and Ferritin levels was recorded. These results indicated that DLM is a toxic pyrethroid pesticide that produced significant Alteration in Iron Homeostasis and inflammatory markers.