A total of 80 random samples of fast foodsrepresented by beef kofta, beef burger, beef shawerma, hawawshi (20 of each) were collected from different fast food restaurants in different districts at Monufia governorate, Egypt. All the collected samples were subjected to determine their quality. The obtained results indicated bacteriological examination and serotyping of Enteropathogenic E. coli isolated from the examined samples of ready-to-eat meat sandwiches. it is obvious that the incidence and serotyping of Enteropathogenic isolated from Salmonella the examined samples of ready-to-eat meat sandwiches Staph. Strains were isolated from the examined samples of ready-to-eat meat products. The obtained results in the present study indicated that meat-based sandwiches were contaminated with different types of microorganisms due to many causes mainly bad hygiene and post cooking contamination.