Toxoplasma gondii is a blood parasite of felids with a wide range of intermediate hosts including humans. The present study was carried out to evaluate the efficacy of acute toxoplasmosis on liver, kidney functions and fertility hormones of infected rats, also the effect of Lincocin and green tea oil and their combination on improving the side effects of acute infection.  A total number of 40 pathogen and Toxoplasma-free Sprague-Dawley rats were divided into four groups as follows: Group (1) non infectednon treated; Group (2) infected non treated, Group (3) infected and treated with Lincocin; Group (4) and infected and treated Lincocin and the addition of green tea. The recorded data revealed a significant elevation in levels of ALT, AST, T. Bilirubin, urea and creatinine and a significant decrease of the levels of albumin, progesterone, and testosterone in infected non- treated rats when compared with those of the non- infected group, while cortisol level was not affected.  It could be concluded that T. gondii could affect liver and kidney functions and adversely affect major reproductive hormones. Therefore, it is recommended for the In Vitro Fertilization (IVF) and fertility centers to investigate T. gondii infection in the serum of infertile men as a routine test and treat the positive cases. Treatments with Lincocin plus green tea could be the drug of choice to avoid side effects of acute toxoplasmosis.