The present study was designed to evaluate the suspected anticancer activity of Solenostemma argel (200 mg/kg body weight/ day) either alone or combined with cisplatin (0.64 mg/kg body weight/day) for 4 weeks against lung cancer induced by DMBA (20 mg/kg bw) for 8 weeks in male Wistar rats.At the end of experiment, blood and Lung samples were collected to assess biochemical and biophysical markers as well histopathological investigations. Biochemical parameters:, serum Tumor suppressor protein (P53) and (P16), Transforming Growth Factor-beta (TGF-β), interleukin-1beta (IL-1β), interleukin-6 (IL-6), Carcino Embryonic antigen (CEA). Lung induced nitric oxide synthase (i-Nos), cyclin dependent kinase-2 (CDK2). The level of significance between mean values was set at p < 0.05. The results of this study also showed that administration of olenostemma argel to lung carcinoma induced rats demonstrated a significant improvement in biochemical parameters and life span as compared to DMBA control rats. The histopathological examinations of this study revealed damage and degeneration in the lung of DMBA treated rats.  Also, lung of Argel and Cisplatin rats showed significant improvement and protection against DMBA harmful effect.