A total number of 160 Wister female rats, 12 -wk. old were taken, weighed and divided into five experimental groups to investigate the effect of streptozotocin (STZ) injection (30 and 60 mg/kg B.W) with and without zoledronic acid (0.15 mg/kg B.W) on some blood serum constituents such as glucose, insulin, calcium, phosphorus and vitamin D. The current results showed that, injection with STZ was associated with a statistically significant elevated in serum glucose, while there was a decrease in serum insulin, calcium and phosphorus. However, zoledronic treatment resulted in a decrease in serum glucose, mean - while it elevate serum insulin, calcium and phosphorus. toward normal Level These results indicated that ZOL acid has beneficial effect on pancreatic biochemical parameters in case of degenerated pancreas.