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38349

Biochemical Study of Anti-Inflammatory Effect of Osteoblastic Activator in Experimental Pancreatic Degeneration in Rat

Article

Last updated: 22 Jan 2023

Subjects

-

Tags

Biochemistry

Abstract

A total number of 160 Wister female rats, 12 -wk. old were , weighed and divided into five experimental groups to investigate the effect of streptozotocin (STZ) injection (30 and 60 mg/kg B.W) with and without zoledronic acid (0.15 mg/kg B.W) on some blood serum constituents such as  interleukins (IL-2, IL-6), immunoglobulin E (IgE) and cortisol. The results indicated that it's paralleled to the published data on the hyperglycemia and inflammatory condition in experimentally pancreatic degeneration. The current results showed that, injection with STZ was associated with a statistically significant elevation in serum IL-2, IL-6, IgE and cortisol but zoledronic treatment with STZ resulted in a decrease in serum IL-2, IL-6, IgE and cortisol. These results indicated that ZOL acid has beneficial effect to slow pancreatic carcinoma induction when treated with STZ at once in experimental animals

DOI

10.21608/bvmj.2018.38349

Keywords

STZ, Zoledronic acid, pancreas

Authors

First Name

Abdel maksoud

Last Name

H.A.

MiddleName

-

Affiliation

Department of Meat Biochemistry, Faculty of Veterinary Medicine, Benha University

Email

-

City

-

Orcid

-

First Name

Omnia

Last Name

M. A.

MiddleName

-

Affiliation

Department of Meat Biochemistry, Faculty of Veterinary Medicine, Benha University

Email

-

City

-

Orcid

-

First Name

El-Bialy

Last Name

M.

MiddleName

-

Affiliation

Department of Meat Biochemistry, Faculty of Veterinary Medicine, Benha University

Email

-

City

-

Orcid

-

Volume

35

Article Issue

1

Related Issue

5726

Issue Date

2018-09-01

Receive Date

2019-07-02

Publish Date

2018-09-01

Page Start

164

Page End

170

Print ISSN

1110-6581

Link

https://bvmj.journals.ekb.eg/article_38349.html

Detail API

https://bvmj.journals.ekb.eg/service?article_code=38349

Order

17

Type

Original Article

Type Code

812

Publication Type

Journal

Publication Title

Benha Veterinary Medical Journal

Publication Link

https://bvmj.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023