Pomegranate is a drought tolerant and long lived plant which grows popularly in arid and semiarid zones in the Mediterranean countries. Pomegranate was reported to have antimicrobial, anti-inflammatory, anti-tumor, anti-hepatotoxic, antiviral, anti-diabetic activities and they can improve oral, skin and cardiovascular health. Sucrose is a non-reducing disaccharide made up of 50% glucose and 50% fructose and has a moderately high glycemic index. High-sucrose diets have been used in animal models to induce well-characterized metabolic dysfunctions including cardiovascular risk factors, insulin resistance, dyslipidemia and hypertension. The present research aimed to evaluate the effects of pomegranate grinded peel extract supplementation on blood parameters of male rabbits stressed by high sucrose diet for 4 months, Through evaluation of serum total lipids, triacylglycerols, total cholesterol, HDL-c, LDL-c, VLDL-c and atherogenic indices, in addition to serum urea, creatinine, glucose, testosterone, zinc and copper concentrations. High sucrose supplementation induced a significant increase in Serum total lipids, triacylglycerols, total cholesterol, LDL-c, VLDL-c, atherogenic indices, glucose, testosterone and copper concentrations, in addition to non-significant increase in serum urea, creatinine concentrations. On contrast, it exhibited a significant decrease in serum HDL-C and zinc concentrations. Pomegranate peel powder supplementation was able to mitigate and ameliorate stress induced by high sucrose ration and showed pronounced curative effect against hyperlipidemia and deviated serum atherogenic indices as well as maintained glucose, testosterone copper and zinc toward control levels. The results of the present study suggested that pomegranate has the potential to exert curative effects against hyperlipidemia.