The study aimed toinvestigate the immunomodulatory and antiparasitic effects of garlic extract- loaded zinc oxide nanoparticles in comparison to pure garlic extract against  rabbit hepatic coccidiosis. Sixty male rabbits were allocated into four groups; Group 1: control, Group 2 (infected group): rabbits were inoculated orally with 2 x 10³ sporulated oocyst of E. stiedae , Group 3: rabbits were infected as group 2 and treated with garlic extract (500 mg/kg b.w) and Group 4: rabbits infected and treated with garlic extract nanoparticles (500 mg/kg b.w). Five rabbits of each group were scarified at 7^th, 14^th and 21^th day post inoculation (dpi).  Biochemical, haematology and antioxidant parameters were evaluated. Fecal samples were collected at 19^th day to calculate the number of oocyst. Results revealed: hemoglobin concentration and PCV significantly increased in group 4 when compared to group 2, and platelets count of group 3 significatly increased when compared with group 2. Significant decreases in ALT, AST, Alkaline. phosphatase, bilirubin were detected in groups 3 and 4 compared with group 2, but significant decreases in MDA and SOD in groups 3 & 4 compared with group 2. Group 2 had significant increases in ALT, AST, Alkaline phosphatase, bilirubin, MDA and SOD activities when compared with control group. Significant increases in AST and ALP activities were detected in group 4 in comparison with group 3. Group 3 had a significant decrease in SOD when compared with group 4. Group 3 and 4 induced significant reduction in fecal oocyst count compared with group 2. Conclusively, garlic crude extract and garlic nanoparticles had antioxidative and anti-parasitic effect on hepatic coccidiosis of rabbit.