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38198

Effectof Castration on Some Immunological Aspects in Male Albino Rat

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Physiology

Abstract

The current study aimed to evaluate the effect of surgical and chemical castration on some immunological aspects in adult male albino rats. A total number of forty adult male albino rats weighing 220±20 g and averaging 4 months old were used. Rats were divided into four equal groups. Group 1, intact control group; group 2, sham castrated group; group3, surgically castrated group and group 4, chemically castrated group. Relative thymus and spleen weight, peripheral total and differential leukocytic count and relative expression of TNFα gene were recorded at 2 and 4 weeks after castration. The obtained results revealed that surgical and chemical castration resulted in a significant increase in relative thymus and spleen weight. Peripheral total leukocytic count was significantly increased in surgically and chemically castrated groups as compared to intact control and sham groups. Differential leukocytic count revealed a significant increase in lymphocyte number and a significant decrease in neutrophil number in surgically and chemically castrated groups as compared to intact control and sham groups. Real-time quantitative PCR analysis of TNFα gene expression in spleen revealed that surgical and chemical castration resulted in significant up regulation of TNFα gene expression. So, it concluded that surgical and chemical castration improved immunity and testosterone has an immunosuppressive effect in adult male albino rats.

DOI

10.21608/bvmj.2018.38198

Keywords

surgical, chemical, castration, Rats, Immunological aspects

Authors

First Name

S. M.

Last Name

Habak

MiddleName

-

Affiliation

Physiology Department, Faculty of Veterinary Medicine, BenhaUniversity, Egypt

Email

-

City

-

Orcid

-

First Name

M. E.

Last Name

Azab

MiddleName

-

Affiliation

Physiology Department, Faculty of Veterinary Medicine, BenhaUniversity, Egypt

Email

-

City

-

Orcid

-

First Name

R. S.

Last Name

Ismail

MiddleName

-

Affiliation

Physiology Department, Faculty of Veterinary Medicine, BenhaUniversity, Egypt

Email

-

City

-

Orcid

-

First Name

A. A.

Last Name

Nafeaa

MiddleName

-

Affiliation

Physiology Department, Faculty of Veterinary Medicine, BenhaUniversity, Egypt

Email

-

City

-

Orcid

-

Volume

35

Article Issue

1

Related Issue

5726

Issue Date

2018-09-01

Receive Date

2019-07-01

Publish Date

2018-09-01

Page Start

76

Page End

83

Print ISSN

1110-6581

Online ISSN

2974-4806

Article File

BVMJ_Volume 35_Issue 1_Pages 76-83.pdf

PDF . 625.2kB

Link

https://bvmj.journals.ekb.eg/article_38198.html

Detail API

https://bvmj.journals.ekb.eg/service?article_code=38198

Order

9

Type

Original Article

Type Code

812

Publication Type

Journal

Publication Title

Benha Veterinary Medical Journal

Publication Link

https://bvmj.journals.ekb.eg/

MainTitle

Effectof Castration on Some Immunological Aspects in Male Albino Rat

Details

Type

Article

Created At

22 Jan 2023