Nutritional Muscular Dystrophy (NMD) is a disease of lambs results from a selenium and/or vitamin E deficiency. This
study was applied on 20 NMD lambs and 20 control native breed lambs from Qalyubia Governorate, with ages ranged
from 1 to 4 months, in order to explore the effects of NMD clinical and hematobiochemical changes in lambs. Affected
lambs showed sternal recumbency, stiffness, trembling and muscle tremors, hard swollen muscle and the lamb adopted
lateral recumbency. The diseased lambs had significant (P<0.05) decreases in the serum Se and vitamin E. The RBCs
count, Hb content and PCV% were significantly decreased (P<0.05) in NMD lambs. On other hand, the MCV and MCH
were significantly increased (P<0.05) in NMD lamb compared to control. The activities of ALT, AST, CPK, LDH and
MDA were significantly increased (P<0.05) in NMD lamb compared to control group. The SOD and GSH-Px were
significantly decreased (P<0.05) in NMD lamb compared to control. It was concluded that vitamin E and Se deficiency
result in NMD which associated with alteration in clinical and hematological parameters