This study designed to evaluate the hepatoprotective effect of stem cells only or stem cells and levamisole on
experimentally Carbon tetrachloride (CCl₄) induced liver damage by evaluation of haematological parameters,
biochemical parameters, immunological parameters and histopathological findings. Sixty (60) Wister rats were
divided into four groups with 15 animals in each group. Group (1): normal group. Group (2): rats injected with
CCL₄ (0.2ml/100gm) s/c twice a week for 9 weeks. Group (3): rats injected with CCL₄ then given MSCs
(3x10⁶ cell) I/v once a week for 4 weeks. Group (4): rats injected with CCL₄ then given levamisole (2.5mg/kg)
three successive days for 4 weeks and stem cells (MSCs) (3x10⁶ cell) I/v once a week for 4 weeks. Results
showed that injection of CCL₄ lead to significant increase in activity of hepatic enzymes (AST, ALT, ALP)
and Bilirubin level while it decreased serum total protein, albumin, IL- 6, Phagocytic index, Phagocytic %,
IgG and IgM. While after treatment with stem cells only or stem cells and levamisole lead to significant
decrease in activity of hepatic enzymes (AST, ALT, ALP) and Bilirubin level while it increased serum total
protein, albumin, IL- 6, Phagocytic index, Phagocytic %, IgG and IgM