To elucidate the macroscopical and microscopical structure of dog's lacrimal gland, 15 adult dogs (Canis familiaris) were
utilized in this study. Macroscopically, the lacrimal gland was located on the dorsolateral aspect of the eyeball and
bounded dorsolaterally by the orbital ligament, zygomatic process of the frontal bone and frontal process of malar bone.
Its shape was nearly rectangular with the average width (1.38 ± 0.13 cm) and length (1.52 ±0.12 cm). In between the
dorsal and lateral rectus muscles, the lacrimal artery, vein and nerve were observed. Microscopically, the lacrimal gland
was enveloped by the fibromuscular capsule and lobulated. Each lobule was formed of secretory endpieces and ducts.
The secretory endpieces were mucous and serous. However, the mucous type was predominant. The lining cells of the
secretory endpieces expressed a positive reaction to alcian blue and Periodic acid Shiff. A series of duct system within
the lobules and septa was seen. The scanning electron microscopic examination revealed that the secretory endpieces
covered with granular secretory substance. Several crystals with sharp taper ends were seen around the secretory
endpieces