This work aimed to evaluate the efficacy of a commercial inactivated Salmonella vaccine in quails where sixty of three
weeks old quails were vaccinated twice via subcutaneous route while another forty birds were kept without vaccination
as non-vaccinated control. The immune response of vaccinated birds was estimated by microagglutination test for
Salmonella Enteritidis (SE) and Salmonella Typhimurium (ST) antibodies that revealed a detectable increase in antibody
titers in vaccinated birds in comparison with the unvaccinated ones. The protection rate of vaccinated quails post challenge
with locally isolated Salmonella Enteritidis (SE) and Salmonella Typhimurium (ST) strains were 83.3% and 90%
respectively. Salmonella was recovered from vaccinated challenged quails at ratio ranged from 23.3% -33.3% for SE and
20% - 30% for ST from the heart blood, liver, spleen and caecal junction post challenge. The results of challenge test
showed that vaccinated quails were effectively protected against virulent strains of Salmonella Enteritidis (SE) and
Salmonella Typhimurium (ST)