Myocardial infarction (MI) is characterized by an inequity of coronary blood supply and demand, which results in
myocardial ischemic injury and damages the cardiomyocytes. Isoproterenol (ISO) is a synthetic catecholamine cause
toxicity leading to severe stress in the myocardium of experimental animals. The aim of the present article is to investigate
cardioprotective activity of cranberry extract against ISO-induced cardiotoxicity in adult rats. Oral administration of
cranberry extract at a concentration of 75 and 150 mg/kg b.wt. daily for 28 days showed a significant protection againstinduced
alteration in plasma total cholesterol (TC), triacyclglycerols (TG), high density lipoprotein (HDL-C), low density
lipoprotein (LDL-C), tumor necrosis factor-alpha (TNF-α) and nitric oxide (NO) as well as cardiac superoxide dismutase
(SOD), glutathione peroxidase (GPx), reduced glutathione (GSH), catalase (CAT) levels. In addition, cranberry extract
reduced plasma Creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) as
well as cardiac thiobarbituric acid reactive substances (TBARS) levels (MDA) as compared to control group. In
conclusion, cranberry extract renders resiliency against isoproterenol cardiotoxicity due to its antioxidant and free radical
scavenging activity