The ameliorative effects of some different antimycotoxicosis compounds (AMCs) against the adverse effects induced by intoxication of dietary aflatoxin (AF) and/or ochratoxin (OT) on the immune system performance in broiler chicks were investigated.AF (23 ppb), OT (17 ppb) and mixed doses were fed and in association with antimycotoxin feed additives; product A (combination of Eubacterium BBSH⁷⁹⁷ and Trichosporon mycotoxinivoran, plant extract, algae extract) or product B (nano-clay, seaweed extract, yeast cell wall, diatomaceous earth) from 1 day old chicks to 21 day. The intoxicated chicks treated with AMCs; product C(combination of bacterial cell wall extract, oligosaccharides, L-form bacteria extract, group of mycotoxin biotransforming enzymes, organic acid and salts, hepatic and renal tonic and vitamins)or product D in drinking water (isomalto-oligosaccharide, micronized-mannan oligosacharide, lactobacillus extract and cholestyramine) were used in the drinking water of 2 weeks old chicks after appearance of signs. Results revealed that chicks intoxicated with AF and/or OT showed significant (P<0.05) decrease in the relative weights of the main immune organs and the antibody titers against vaccines of Newcastle disease (ND) and Infectious bursal diseases (IBD) viruses, in addition to significant (P<0.05) increase in the cumulative histopathological lesion scores of thymus, bursa of Fabracius and spleen. The adverse effects of AF and/or OT on the relative weights and the histopathological lesion scores of the tested immune organs and the antibody titers against ND and IBD vaccination were significantly (P<0.05) improved with dietary supplementation of AMCs products A or B. While the treatment of the intoxicated chicks with AMCs products C or D in the drinking water showed partially and temporarily improvement in the relative weights and the histopathological lesion scores of the tested immune organs and did not improve the negative effects of AF and/or OT on the antibody titers against ND and IBD vaccines.