Osteoarthritis (OA) is the most common disease of joints in adults around the world. Osteoarthritis was induced in rats
by intra-articular injection of 2 mg/kg b.wt of monosodium-iodoacetate (MIA). Thirty six male, albino rats were divided
into four equal groups. 1^st group was not subjected to any intervention and was used as normal control. 2^nd group (OA -
induced group) received injection of MIA intra-articular. 3^rd group ( OA+ curcumin treated group) injected MIA and
treated with 200 mg/kg b.wt of curcumin orally and daily / 28 day. 4^th group ( curcumin normal group) received 200
mg/kg b.wt of curcumin orally and daily / 28 day. Blood samples were collected at 28^th day. The obtained results showed
a significant increase in MDA level and SOD activity in MIA induced OA. On the other hand, a significant decrease in
GSH, GPx, CAT and GAG were observed in OA induced rats. Curcumin treatment in OA induced rats significantly
increased GSH concentration , GPx, CAT and GAG activities with marked decrease in MDA concentration. In
conclusion, the present study demonstrated that curcumin administration provided an effective protection and treatment
against OA and oxidative damage in MIA injected rats.