This paper aims to determine the obstacles and challenges facing adopting electronic inventory control systems in four-star hotels in Cairo. This study is based on a quantitative research approach. In order to achieve the objectives of the study, the 150 questionnaire forms were distributed to stores department staff (stores manager, assistant stores manager, store keeper, assistant store keeper, and inventory controller) in 30 four-star hotels located in Greater Cairo. The number of valid questionnaires for analysis is 136 with a response rate (90.6%). The data analysis was conducted through the statistical package of social sciences SPSS (version 26.00). The current study found that there are some obstacles that prevent and reduce the optimal level of adopting the electronic inventory control systems in stores departments in four-star hotels in Cairo, despite the importance of such electronic systems in inventory monitoring. The obstacles facing stores departments included technical, organizational, financial, and security obstacles. This is confirmed by the study urging more considerable attention to this aspect and by trying to overcome these obstacles.