Background: Patellofemoral pain syndrome (PFPS) is anterior knee pain that is increased by ascending or descending stairs or prolonged sitting with bent knees in absence of significant structural changes. The current study aims to assess the outcome of arthroscopic denervation of the patella using a radiofrequency ablation device in the management of resistant patellofemoral pain in absence of malalignment and patellofemoral maltracking. Methods: This prospective study was conducted in Orthopedic Surgery department at Benha University hospital on 25 patients with resistant patellofemoral pain syndrome. Results: one year Post-operatively, there was high statistically significant improvement in VAS on comparing preoperative (p < 0.001). There were no significant changes in pain VAS 6 months postoperatively and at 1year postoperatively (p>0.05). Six months Post-operatively, there was high statistically significant improvement in Kujala on comparing preoperative (p < 0.001). Also, one year Post-operatively, there was high statistically significant improvement in Kujala on comparing preoperative (p < 0.001). One year Post-operatively, there was high statistically significant improvement in Lysholm score on comparing preoperative (p < 0.001). There were no significant changes in Lysholm score 6 months postoperatively and at 1year postoperatively (p>0.05). Complications were found in eleven cases in our study, nine cases complicated by quadriceps muscle atrophy, one case with DVT and one case had anterosuperomedial (ASM) portal synovial sinus. Conclusion: Arthroscopic patellar denervation is a simple procedure that yields good results, improved patient satisfaction, and leads to non-significant complications in the management of resistant patellofemoral pain syndrome.