Background: COVID-19 is fatal disease caused by SARS-CoV-2. It spread more rapidly than SARS, MERS & common cold due to increase globalization & adaptation of the virus in every environment. SARS-COV-2 is the seventh known coronavirus which includes sever acute respiratory syndrome (SARS) & Middle East Respiratory Syndrome (MERS). The structure of the virus is behind its varying symptoms & the defense mechanism. It is important to consider respiratory, gastrointestinal & neurological symptoms. Also travel history & close contact of positive COVID-19 cases as well. Prompt recognition of imaging patterns based on the infection time course is essential for not only understanding the natural history of infection, but also for helping to predict patient evolution & possible complication development. Subject and method: We report a female patient case of COVID-19 with respiratory & gastrointestinal manifestations, imaging findings & detection of response to the treatment regimen.  Result: Marvelous response of the treatment regimen & complete cure of the respiratory & gastrointestinal symptoms. Conclusion: The course of coronavirus 2019 disease can't be predicted. The discussed treatment protocol is an evolution in the age of COVID-19.