Background: Chronic wounds constitute a real challenge for the clinicians as they do not respond to traditional treatment and they are not rare. Stem cell therapies have emerged as potential treatment of such wounds. Platelet-rich plasma is known to be a rich source of cytokines and growth factors that are important for healing and re-epithelialization of chronic wounds.
Objective:To compare bone marrow derived stem cells and platelet-rich plasma for treating chronic wounds.
Patients and Methods: A prospective randomized comparative study included 30 patients complaining of chronic wounds with average surface area less than 10 cm2 divided into 2 groups; group (A) were managed by injection with BMSCs and group (B) were managed by injection with PRP. The study was done at Al-Azhar University Hospitals, Center for Genetic Engineering at faculty of science, Al-Azhar University and Elsalam specialized hospital.
Results: Regarding the demographic characteristics of the studied cases including gender, age, causes of the wound and the sites of wound, our results indicated no statistically significant difference between both groups. Regarding the relationship between the percentage of improvement among BMSCs injection patients and the cause of the wound, our results indicated that the longer the period after treatment with BMSCs or PRP, the lesser the size of the wound became.
Conclusion: It could be concluded that each of bone marrow derived stem cells and platelet-rich plasma are effective for the treatment of chronic wounds.