This experimental study was conducted during the spring season of 2018/2019 and 2019/2020 at the Experimental Station of Alexandria University located at Abies, Alexandria, Egypt, to investigate the effect of using compost, Pseudomonas fluorescens, and Arbuscular Mycorrhizal fungus (Glomus intraradices) on the yield and quality of potato tubers (Solanum tuberosum) under three irrigation intervals (every 3, 6 and 9 days). The field experiment was carried out using a randomized complete block design with three replicates. The treatments were controlled, NPK as recommended dose, AMF (G. intraradices), Pseudomonas fluorescens, compost, AMFand Pseudomonas fluorescens, AMF and compost, Pseudomonas fluorescens and compost, AMF and Pseudomonas fluorescens and compost. Results showed that dual inoculation (G. intraradices, and P. fluorescens) and the interaction between dual inoculation (AMF + P. fluorescens) and compost had a significant impact on root and shoot dry weights, plant height, tuber weight, and tuber number/plant of the potato plants at all the irrigation intervals compared to un-inoculated control plants and other treatments. The highest mean values total tuber yield (12.01, and 13.19 ton/fed) for first and second seasons respectively. Plant biomass were (15.77, and 18.55 g) and (149.77, and 165.88 g) for root and shoot dry weights respectively after 90 days. In conclusion, it can be summed up that AMF inoculation combined with PGPR and compost has a positive effect on the growth and quality of the potato crop in drought conditions.